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Should People with AS Genotype Marry?

October 15, 2018

Updated April 2023

If you or your partner have the AS genotype, you may be wondering if it’s safe to get married. This article explores the risks and considerations involved.

Are you considering this question: “Should people with AS Genotype Marry”?

Here we explore the issues around forming significant relationships with people of AS genotype and their implications. No one can make these decisions for another – but having access to accurate information can help those who have to carefully think through and make the best choices for themselves and their families.

Parents with AS genotype may have any number of children with a sickle cell genotype.

“Should people with AS genotype Marry?”

Recently, a client asked us this really important question.

We think there are many people who struggle with this dilemma, particularly in Africa.

This is because there are limited treatment options from poor healthcare access.

And the illness burden is severe.

Putting all the considerations together, we share our reply here for others who may have this on their mind as well.

Your genotype is a very important part of your healthcare status/profile and one of those things that you should know because of the life-changing implications it carries.

What is Sickle Cell Disease?

People inherit Sickle Cell Disease (SCD), and it is present from birth.

  The problem in this condition is that the red blood cells in the blood of a ‘sickle cell warrior’ have changed from the normal ‘circular’ or spherical shape to a sickle shape.

A child with ‘sickle cell anaemia’ has received the sickle genes from BOTH parents.

In a relationship where both partners are AS genotype, it means that for every pregnancy they have together, there is a 25% chance that the child born of the pregnancy would have SS genetic combination i.e. a who will have sickle cell anaemia.

Other forms of sickle cell disease include the AS genotype, when just one sickle gene is inherited.

Or Haemoglobin S-C disease when the person inherits an abnormal S gene and abnormal C gene.

Some Complications of having Sickle Cell Anaemia (SCA) / SS Genotype

People with the condition are prone to several health problems throughout life from childhood.

Some of them are:

  • Episodes of severe pain in the bones and joints called ‘crisis’ that may happen because of cold weather, infection, dehydration, or exertion.
  • Anaemia – people with SCD have low blood (haemoglobin) levels usually, but sometimes because of infection, they can develop even lower blood levels.
    • When they have anaemia, they become very pale, find it difficult to breathe, and are very tired. This can affect their normal body functions.
  • Infections – they easily develop infections like malaria or pneumonia etc. which can increase the risk of anaemia.
  • Blocked blood vessels because of the abnormal sickle cells can cause a syndrome with pain in the chest, fever, and breathing difficulties.
    • This can also affect important organs of the body and their functions e.g leading to certain types of stroke.

So these are some of the problems that people with SCA suffer – FROM CHILDHOOD.

All of these problems could lead to death if not properly managed. People with sickle cell anaemia need VERY Prompt attention when they become ill.

Fast access to pain relief and oxygen is essential; they need injections and intravenous fluids to manage infections, and they may need blood transfusions to treat anaemia quickly.

They need a lot of care and support, but with the right treatment in a timely fashion, they can thrive and lead fulfilled and happy lives.

The decision for 2 people to marry is left to themselves, but we will encourage that they think very hard about the issues, options and implications if they choose to do so when both of them are AS.

Considerations for AS relationships


1. These may centre around the financial and psychological support for the family having a child or children who are SS.


2. The two AS genotype partners can decide to marry and have no children. Or they may decide to marry, have no children and adopt children instead.

3. If they decide to marry and have a family together, they should realise that in each pregnancy, there is a 25% chance that the child that is born from the pregnancy will have the SS genetic combination i.e. having SCD, and can suffer from all of the above problems described.

(Some AS+ AS couples have 1 child with SS, and others have more than one child with SS.)

When an AS+AS couple becomes pregnant, they can have prenatal testing and counselling – this is a procedure carried out early in the pregnancy to determine whether the foetus has the SS gene.

It is not available in every country, and people who want to use this method should check if it is available to them.

The end goal is that if prenatal testing confirms the child will have SCD, a decision may be taken to end the pregnancy at that stage.


4. If they decide to keep the pregnancy, it is important to be aware of the child’s health needs and how prepared they are to meet these needs.

(Remember we said ‘the right treatment in a timely fashion?). Well, these are the KEY Questions you must ask yourselves:

Some Key Questions

*Are there hospitals close by that can manage the condition?

*Is there transportation to get the child to the hospital quickly?

*Do they know what needs to be avoided in children with SS to prevent the risk of developing some of the problems listed above?

*Are they aware of the emergency management and drugs that can be given at home (school) if problems arise?

*Is their home in an area/town/country where there is much support available for people with SS from childhood to adulthood?

Supporting a child with these needs has financial and psychological implications and can have a huge impact on the mental well-being of the entire family.

Some couples can handle this with help from friends and families; some may not.

Concluding Thoughts

These are some of the issues that surround the family with AS+AS parents and are worth considering when making the decision to marry.

Please feel free to contact us if you wish to clarify anything or need more information.

Or comment below if you want to tell us your view of the issue.

The important thing is to realise there are options and for people to decide with their partner which best suits them, and no one else can make this decision for the couple.

Stay Well!

Read More

Editing by AskAwayHealth Team


All AskAwayHealth articles are written by practising Medical Practitioners on a wide range of healthcare conditions to provide evidence-based guidance and to help promote quality healthcare.

The advice in our material is not meant to replace the management of your specific condition by a qualified healthcare practitioner.
To discuss your condition, please contact a health practitioner or reach us directly

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  • Oyheen Morenikeji

    August 2, 2023 9:26 am

    Good morning I and my spouse are both As and we have a daughter which is As can we go ahead to have a second baby… we are both scared

  • Barnabas Victor

    May 18, 2023 11:52 am

    My wife and I are both AS and we want to have children, where can we access the prenatal test?

    • askawayhealth

      May 25, 2023 3:28 pm

      Hi, this depends on which part of the world you are – you can start by speaking with a clinic in your local area who can advice where you can get a referral with a haematologist to discussing counselling and prenatal tests.

  • Israel

    May 9, 2023 9:53 am

    Good morning I and my spouse are both As As and we have both agreed to marry what are the advice you have for us?

    • askawayhealth

      May 9, 2023 2:57 pm

      Hi – sure we can discuss your needs – please use this link to book a meeting with me via our digital concierge.
      We’ve also got resources you can read on the blog

  • Boluwatife owoyele

    May 7, 2023 10:33 pm

    I learn a lot from this

    • askawayhealth_dev

      May 8, 2023 5:02 am

      Glad you find it useful, thanks

  • Kemi

    May 7, 2023 2:49 pm

    This is a lovely article as I have been searching Google for months before I finally found your website. Thanks for putting this up.
    I have been doing abit of research on the internet and I would like to ask if IVF is a solution one can look at for both couple with AS genotype and would like to know the implications.

    Hope to hear form you.

    • askawayhealth_dev

      May 8, 2023 4:35 am

      Hi thanks for your comment and glad you found the post useful.
      Yes, IVF is an option that is used in a process known as Pre implantation genetic treatment
      /diagnosis- you can read more about this here
      You can also explore our other posts by visiting the blog section and using the search bar.
      Best Wishes
      (Reach a Doctor)

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